The harm of ankylosing spondylitis is self-evident. Everyone should be familiar with the cause of ankylosing spondylitis, which is very helpful for the prevention and treatment of ankylosing spondylitis, especially now that it is in the strong The period of high incidence of spondylitis, so you must not take it lightly. So, what is the relationship between ankylosing spondylitis?
What is the relationship between ankylosing spondylitis?
Infectious factors: Some intestinal infections may not be neglected. Enteric Klebsiella pneumoniae can be detected in the stool of patients with ankylosing spine.
Endocrine disorders or metabolic disorders: Because rheumatoid is more common in women, and ankylosing spondylitis is more common in men, it is considered that endocrine disorders are associated with this disease. However, the use of hormone therapy for rheumatoid has not achieved significant results, and the relationship between hormonal imbalance and this disease is not certain.
Age and gender factors: 10 to 30 years old is the high-risk age of the disease. After 40 years of age, the incidence gradually decreases, accounting for only 1%. The ratio of male to female is 10:1. In recent years, a large number of children aged 6-10 years have been found in the clinic, which may be related to the popularity of medical ankylosing spondylitis and the improvement of the diagnostic rate.
Genetic factors: The incidence of ankylosing spine varies among races, with the highest number of North American Indians, white Americans, and blacks about 1/4 of whites. HLA-B27 is an important marker in patients with ankylosing spondylitis, with a positive rate of over 90%. This indicates that ankylosing genetic factors play an important role in this disease.
Other factors: age, physical fitness, malnutrition, climate, soil and water, humidity and cold. Others including trauma, parathyroid disease, upper respiratory tract infection, local suppurative infection, etc. may have a certain relationship with the disease, but the evidence is insufficient.
Why do female friends develop ankylosing spondylitis
Infectious factors: genitourinary infection is one of the important factors causing this disease, pelvic infection It spreads through the lymphatic pathway to the ankle joint and then to the spine, and can also spread to the large circulation to produce systemic symptoms and lesions of surrounding joints, tendons and ocular pigmentation.
Gene factors: The incidence of this disease is closely related to genetic factors. The positive rate of HLA-B27 in ankylosing spondylitis is as high as 90%-96%, and the family genetic positive rate is 23.7%. The incidence of rheumatoid family is 2 to 10 times that of normal people, and the incidence of ankylosing spondylitis is 30 times that of normal people.
Endocrine disorders or metabolic disorders: Because rheumatoid is more common in women, and ankylosing spondylitis is more common in men, it is considered that endocrine disorders are associated with this disease. However, the use of hormone therapy for rheumatoid has not achieved significant results, and the relationship between hormonal imbalance and this disease is not certain. There was no significant increase or decrease in the rate of rheumatoid or ankylosing spondylitis in patients with adrenal hyperfunction.