Relationship between vitamin D and ankylosing spondylitis

Vitamin D is a sterol derivative, and the discovery of vitamin D is the result of people fighting snoring. Vitamin D is not only resistant to rickets, but the role of vitamin D in rheumatology is not underestimated.

Relationship between vitamin D and ankylosing spondylitis

01

What are the effects of vitamin D?

In recent years, studies have found that the active metabolite of vitamin D, 1,25(OH)2D3 (1,25-dihydroxyvitamin D3), in addition to its role in calcium and bone metabolism, It can participate in immune regulation by inhibiting an overactive inflammatory response. Vitamin D supplementation may be beneficial for some autoimmune diseases such as ankylosing spondylitis, systemic lupus erythematosus, and inflammatory bowel disease. Studies abroad have found that vitamin D deficiency is associated with disease activity and osteoporosis in AS with ankylosing spondylitis. The immunoregulatory mechanism of vitamin D and its possible relationship in the pathogenesis of AS and bone metabolism.

1,25(OH)2D3 can promote intestinal calcium absorption, increase bone density, improve bone quality, reduce fracture occurrence, promote fracture healing, increase type II muscle fiber, increase muscle strength and improve body balance Sex, reduce the occurrence of falls, and at the same time have immunosuppressive effects, inhibit the expression of inflammatory factors.

relationship between vitamin D and ankylosing spondylitis

02

What is the direct relationship between dimension D and toughness?

According to relevant studies, the level of vitamin D in serum may decrease in patients with tonicity and may be inversely related to disease activity, susceptibility and quality of life. The possible reasons for the negative correlation between the two are: for the pathogenesis of ankylosing spondylitis, in addition to genetic factors, immune factors and microbial factors are also involved. In patients with ankylosing spondylitis, IL-2 and IL-6 are significantly elevated, while active vitamin D inhibits these factors, thereby inhibiting the susceptibility and disease activity of tonic. The enhancement of calcium absorption by vitamin D will also reduce the risk of osteoporosis and fracture, improve the quality of life of patients with tonicity, and at the same time, due to the use of immunosuppressants, it can aggravate the deficiency of vitamin D in patients with autoimmune diseases. The above suggests that vitamin D is closely related to the occurrence and development of autoimmune diseases.

relationship between vitamin D and ankylosing spondylitis

04

The relationship between osteoporosis and vitamin D caused by rigidity?

Strong patients should consciously closely monitor and intervene in the early stages of the disease to reduce bone mass and osteoporosis in ankylosing spondylitis. Bone mineral density determination can be used as a routine examination and AS The treatment of secondary osteoporosis pays sufficient attention to avoid serious complications such as spinal compression fractures in the late stage of ankylosing spondylitis. If osteoporosis has already occurred, it should be treated under the guidance of a doctor, supplemented with calcium and active vitamin D. In addition, patients with ankylosing spondylitis can get more sun, which can increase the body’s vitamin D processing and synthesis can promote calcium absorption, but also prevent osteoporosis.

relationship between vitamin D and ankylosing spondylitis

05

What are the ways to supplement vitamin D?

1. Eat more foods rich in calcium and vitamin D: Calcium helps strengthen bones, reduces the effects of inflammation on bones, and can eat more dairy products, soy products, etc. Vitamin D helps Calcium absorption, sea fish, animal liver, nuts and other foods are high in content.

2, but proper sun exposure is the best choice for getting vitamin D.

3. Moderate reduction of carbohydrate intake: Foreign scientists have found that in patients with tonic, the experimental group of low-starch high-protein diet is generally milder than the control group of ordinary diet.