Digititis is a cheap, effective drug for the treatment of heart failure, which not only increases myocardial contractility, dilates peripheral blood vessels, reduces pre- and post-cardiac load, and improves hemodynamics, It has the effects of increasing baroreceptor sensitivity, anti-sympathetic activity and vagus nerve, reducing renin secretion, inhibiting renin-angiotensin-aldosterone system, and improving neuroendocrine function in patients with heart failure.
However, in recent years, with the development of medicine, it has been found that digitalis as a positive-muscle drug has certain significance for the treatment of heart failure, but it improves the symptoms of heart failure and improves the quality of life. The prevention and delay of myocardial remodeling and other aspects have little significance, and its limitations in combination therapy are very large. The common toxic reactions of digitalis preparations are:
gastrointestinal response: Loss of appetite is the first symptom of poisoning, followed by nausea, vomiting, and occasional gastrointestinal bleeding.
Nervous system symptoms: Typical headaches, fatigue, insomnia, depression, dizziness, and hallucinations.
Visual abnormalities: Symptoms such as yellow vision, green vision, red vision or blurred vision, and flash may occur.
Heart aspects: induced arrhythmia and increased heart failure.
Today, let’s take a look at the toxic effects of digitalis drugs (such as dobutamine, dopamine, phosphodiesterase inhibitors, levosimendan, etc.).
1, digitalis and adrenalin and its similar drugs
digitalis can strengthen the heart’s contractility, blood pressure, adrenaline and Similar drugs (such as norepinephrine, etc.) also have the same effect, so the combination of the two can easily cause tachycardia and lead to heart failure.
2, digitalis and liushen pill and Tongyusan gram
The main ingredients of Liushen Pills are glutinous rice, and the hydrolyzate is scorpion venom. The structure is similar to digitalis. If it is used in the rain, it is prone to poisoning reactions. There are also drugs that contain glutinous rice cakes, such as Tongyu San, which needs attention.
3, digitalis and ginseng are similar to each other
The molecular structure of ginseng is similar to that of digitalis, and its cardiotonic effect is mainly direct excitement. Myocardium, humans participate in the combination of digitalis, can enhance each other, prone to digitalis poisoning reaction. In particular, patients should use ginseng with caution during the treatment of digoxin. If they need to be combined, the dosage should be adjusted appropriately.
4, digitalis and Ephedra drugs and their preparations
When taking digitalis drugs, ephedra and Chinese patent medicines containing ephedra should be used with caution. Because ephedrine contains ephedrine, if it is taken with digitalis, it will cause toxicity to the heart.
4, digoxin and magnesium sulfate with grams
magnesium sulfate can accelerate intestinal peristalsis, and the combination of the two drugs can make digoxin The absorption is reduced, the blood concentration is lowered, and the effect is weakened.
5, digoxin and activated carbon phase
activated carbon has adsorption, the two drugs will affect the efficacy of digoxin. If you take digoxin for 2-3 hours and then take activated carbon, there is no significant effect.
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