“Detailed” HLA-B27 “yin” and “yang” and the relationship between ankylosing spondylitis!

HLA-B27 has a positive rate of more than 90% in patients with ankylosing spondylitis, while only 3% of the average person is positive. However, other HLA-B27 antigens such as psoriasis, ulcerative colitis, and Crohn’s disease are also positive. Therefore, HLA-B27 positivity is not necessarily ankylosing spondylitis, but it is more likely. Currently, HLA-B27 is still one of the methods for examining early ankylosing spondylitis.

What is HLA-B27?

HLA is the human leukocyte antigen. HLA-B27 is present in human leukocytes and An antigen directly related to chromatin. HLA-B27 is mainly responsible for mutual recognition and induction of immune responses between cells in the immune system, regulating the function of immune response.

HLA-B27 antigen The physiological function is to carry a presented bacterial polypeptide, and the complex formed by the bacterial polypeptide and HLA-B27 activates CD8+ T lymphocytes, which leads to spondyloarthropathy.

HLA-B27The probability of a positive tonic is 90%

The latest record in the Clinical Medicine section of the International Journal of Anesthesiology and Resuscitation states that ankylosing spondylitis (AS) is A common autoimmune chronic inflammatory disease occurs in young men. The disease is difficult to diagnose early. Recent studies have shown that the detection of HLA-B27 antigen has a high correlation with AS, and about 90% of AS patients HLA-B27 is positive, but 10% of patients are still negative for HLA-B27. That is to say, HLA-B27 can be used as an important indicator for early clinical diagnosis. One, but can not exaggerate the diagnostic role of HLA-B27, especially in patients with negative HLA-B27.

HLA-B27Negatives can not rule out toughness

The positive rates of HLA-B27 in patients with ankylosing spondylitis vary widely from country to country, with 22% being reported as low, 90% being mostly, and as high as 100%. On the other hand, 10% to 78% of patients with ankylosing spondylitis do not have HLA-B27, which is HLA-B27-negative, they also have ankylosing spondylitis, which indicates HLA-B27 and Ankylosing spondylitis is not absolutely relevant.

HLA-B27Check as a reference for diagnosis of tonicity

The study found that normal people check HLA-B27 is generally negative, only 3% are positive, it has been proved that HLA-B27 positive patients are more than 100 times more likely to have ankylosing spondylitis in HLA-B27 negative patients. Therefore check HLA-B27 It is helpful for the diagnosis and differential diagnosis of early ankylosing spondylitis.

HLA-B27Positive may also have these diseases

The same fashion Other diseases: such as psoriasis, ulcerative colitis, Crohn’s disease, Whipple’s disease and other diseases HLA-B27 antigen is also positive.

Therefore, HLA-B27 positivity is an important diagnostic criterion for ankylosing spondylitis, but it is not the only and absolute standard.