Infographic: Can antidepressants stop working?
Yes. Some people develop tolerance to antidepressants, seeing fewer results than a previously-aided drug. This process is often called ADT tachyphylaxis.
Estimates vary, but research shows that 25% of those taking antidepressants for depression will eventually develop tolerance. This number increases to 42% for people diagnosed with dysthymia, a type of long-term depression.
People who have antidepressant tolerance have many choices. They can look for a clinical evaluation to make sure they are depressed and not bipolar. They can ask their psychiatrist to help them turn to a new drug. They can also look for additional treatments such as psychotherapy.
- Antidepressant dependence and withdrawal [PDF]. (2018). Integrated Parliamentary Group on Pre-selected Drug Addiction. Retrieved from https://bit.ly/2FsMQrV
- Hall-Flavin, D. K. (2018, Jan. 31). Antidepressants: Can they stop working? Retrieved from https://mayocl.in/2H3GkKg
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